Offres d’emploi

Medical Director

Responsibilities:

As a Medical Director, you are responsible for providing medical and scientific input into the Study Team and into the Project Teams. You are in charge of planning, designing, developing, executing and interpreting clinical studies. Your main responsibilities are:

• Design clinical development plans, optimize and execute them efficiently and effectively.
• Drive the selection of sites for clinical studies, identify investigators and opinion leaders.
• Write or review study synopsis, protocols, reports and documents (g. CRF, ICF and TMF) for regulatory agencies.
• Ensure medical monitoring of clinical studies.
• Responsible in evaluating adverse events and handling safety information as appropriate, for the management of safety review boards, CROs and other vendors for study and/or safety-related issues.
• Serve as the primary medical liaison to the investigators, opinion leaders, clinical leaders and medical teams of pharma partners.
• Develop and maintain a network of medical experts in the field and represent PDC*Line in interactions with investigators, at meetings and conferences.
• Provide direction on all clinical matters to the PDC*line teams.
• Provide review and query of overall clinical data sets, clinical laboratory and author reports.
• Participate in medical writing of regulatory documents (IND, briefing documents, etc).
• Coordinate and oversee the execution of drug safety process. In collaboration with the clinical team and CRO, you are responsible for safety documentation for clinical trials.
• Participate in the development plan strategy with the other members of management and in the R&D plan development lead by the CSO.

Profile:

• Medical Degree (MD) with strong scientific background and medical practice experience, a fellowship or equivalent in (immuno-)oncology is a plus.
• Experience in a pharmaceutical or biotech company, especially in early stage, exploratory clinical development of drugs and biologics.
• At least 5 years’ experience in performing early development clinical activities and safety assessment activities.
• At least 2 years of successful experience managing and directing a study or project team.
• Working knowledge of GCP, ICH guidelines, EMA and FDA regulations.
• Ability to work in a small, yet international environment with complex issues.
• Excellent organizational, communication and interpersonal skills.
• Effective time, cost and resource management skills.
• Ability to lead and motivate personnel.

Offer:

• An interesting position within a high-potential clinical stage biotech company.
• The opportunity to work in a human-sized and multicultural team environment.
• A variety of interesting contacts with international exposure.
• An attractive salary package in line with the position responsibilities and your experience. 

Nous traitons votre candidature rapidement et de manière strictement confidentielle.

Senior Scientist

As a Senior Scientist, you report to the Head of Pharma Development and to the CEO in order to lead the company’s therapeutic protein development program(s) from preclinical to clinical stage. You are responsible for performing experiments and managing the project. You bring the company’s promising investigational product to clinical proof of concept by combining internal and external resources.

Your main responsibilities are as follows:

• Lead the scientific program of the investigational product development by performing experiments.
• Develop new processes to test in vitro the investigational product(s).
• Coordinate in vivo preclinical experiments with external collaborators/providers/CROs.
• Report results at R&D/Comex meetings.
• Manage scientific reporting for obtained grants and find new grant opportunities.
• Provide CSO/Head of Pharma with innovative R&D projects to develop product portfolio.

Profile:

• You are Ph.D, Vet.D or M.D with at least 5 years of experience in pharma developments.
• You have an experience and expertise in protein development as IMPD.
• You are experienced with cell-based assays and in vivo experimentation
• Knowledge of quality control processes and microbiota field would be a plus
• Rigorous, detail-oriented, autonomous, committed and flexible.
• Excellent oral and written communication skills in English and French.
• Strong team spirit and excellent interpersonal skills

Offer:

• A challenging scientific position within a high-potential innovative biotech company.
• To work in a human-sized, innovative, collaborative and respectful environment.
• To take part in a challenging and cutting-edge development program.
• An attractive compensation package in line with the position’s responsibilities and your experience.

Nous traitons votre candidature rapidement et de manière strictement confidentielle.

Research Assistant – Virology and Serology

Function :

Reporting to the Associate Director, Operations and working closely with Principal Scientists, the Research Assistant, Virology and Serology, will work within a team focusing on the characterization of the cellular and of the humoral immune response. The main responsibilities will include the development and execution of viral neutralization assays, foci forming unit assays, Luminex and ELISA assays.

Tasks include :

• Perform viral and other serological assays according to current standard operating procedures;
• Participate to the writing and/or to the review of method SOP and worksheets;
• Manage reagents inventories and orders;
• Participate to the technical management of the laboratory;
• Perform work according to internal quality standards, apply relevant Quality System procedures and participate to the continuous improvement of Quality documents;
• Attend relevant internal training activities;
• Depending on the experience level of the candidate, additional Research Assistant Level 2 tasks may include:
  • Act as a leader in the laboratory for specific studies;
  • Work with the Principal Scientist to prepare experimental plans needed for the conduct of immune monitoring assays;
  • Participate in the development and qualification/validation of complex methods;
  • Participate in experiment planning and problem solving.

Profile of the applicant :

The applicant must hold a bachelor degree or a master’s degree (or the equivalent) in a life science discipline such as biology, medical biology or biochemistry/biotechnology. A minimum of three (3) years demonstrated experience in techniques related to virology and humoral immunology is required.

The applicant must :

• Demonstrate excellent organisational skills.
• Demonstrate schedule adaptability and flexibility.
• Be willing to actively participate to the generation, the implementation and the continuous improvement of laboratory processes.
• Be willing to work in a Quality environment (ISO17025, GCLP, GMP) and apply good documentation procedures (GDP).
• Be functional in French (spoken and written) and have a functional knowledge of written English. Knowledge spoken English is an asset.

Offer :

• Full time permanent contract, with possibility of rapid start.
• Diversified tasks and responsibilities and interesting projects.
• A professional, dynamic and stimulating work environment.
• Training and development opportunities.
• A competitive salary package including benefits, adapted to your experience and the context.

Nous traitons votre candidature rapidement et de manière strictement confidentielle.

Chimiste R&D
Peintures UV

Responsabilités :

En tant que Chimiste R&D, vous formulez des peintures photo-polymérisables (UV) adaptées aux supports plastiques pour développer la gamme de produits de DSCOLOR.

Vos responsabilités sont les suivantes :

• Développer et réaliser des formulations et nouvelles peintures photo-réticulables de DSCOLOR sur supports plastiques en laboratoire.
• Veiller à la qualification et validation des formulations en laboratoire selon les cahiers des charges de l’automobile et de la cosmétique.
• Réaliser les essais industriels, le scale-up et les validations sur le terrain (production).
• Prendre contact avec les fournisseurs de matières premières.
• Participer à différents salons de représentation.
• Rapporter l’évolution des démarches de manière régulière et structurée vers le responsable.

Profil :

• Vous êtes titulaire d’un Master/ Ingéniorat ou Doctorat en chimie ou équivalent par expérience.
• Vous disposez d’une forte expérience en formulation de peintures photo-réticulables (photo-polymérisation) et UV DUAL CURE sur des supports plastiques.
• Bonne connaissance des résines UV (uréthanes acrylates et polyesters acrylates) ainsi que des photoamorceurs UV pour systèmes pigmentés.
• Une expérience dans des systèmes 2K polyuréthanes est un plus.
• Expérience avérée dans le domaine des peintures pour pistolage industriel.
• Vous communiquez aisément en Français et disposez de bonnes connaissances en Anglais (oral et écrit).

Offre :

• Intégrer une entreprise reconnue internationalement et en pleine croissance.
• Une fonction challengeante avec un réel impact sur la société.
• Un salaire attractif accompagné d’une assurance hospitalisation et d’une assurance groupe.
• Un contrat à temps plein en CDI.

Nous traitons votre candidature rapidement et de manière strictement confidentielle.

CMC Manager

Responsibilities:

As a CMC Manager, you support day-to-day CMC internal and external activities in terms of process, technical expertise and operational trouble shooting. You coordinate CMC operations in collaboration with other departments and suppliers.

Your main responsibilities are:

• Monitor in-house and external CMC activities.
• Provide technical expertise for the drug substance (DS) synthesis and processability.
• Support drug product (DP) technical and planning activities.
• Attend both drug substance (DS) and drug product (DP) key productions.
• Identify potential analytical, processing, stability and compliance issues. Troubleshooting.
• Review certificate of analysis, batch records and other technical documents.
• Participates in the regular communications with the CDMOs and technology providers, discussing data, planning.
• Liaise with other departments to provide them the requested CMC information.
• Support in writing and reviewing CMC sections of the IMPD.

Profile:

• BSc or MSc degree in Chemistry. Knowledge of pharmaceutical technology will be a plus.
• 3 -5 years CMC experience in small molecules, mainly in drug substance (DS).
• Solid experience in analytical, manufacturing and GMP.
• Good understanding of synthesis, process development and process transfers implementation.
• Agility, rapid response to changes.
• Ability to work autonomously and to collaborate with a group in a goal- and team-oriented setting.
• Effective communication skills.
• Fluency in English (written and spoken).
• Prepared to travel to the Spanish site and the CDMO sites around 15% of your work time.

Offer:

• An interesting position within a high-potential clinical stage biotech company.
• The opportunity to work in a human-sized and multicultural team environment.
• A variety of interesting contacts with international exposure.
• An attractive salary package in line with the position responsibilities and your experience.

Nous traitons votre candidature rapidement et de manière strictement confidentielle.

Head of Pharma Development

As a “Head of Pharma”, you lead the company’s therapeutic protein development program(s) from preclinical to clinical stages. Reporting to the CEO, you are responsible for strategic initiatives to bring our very promising investigational product to clinical proof of concept by combining internal and external resources.

Your main responsibilities are as follows:

• Lead A-Mansia’s pharmaceutical development and manage its drugs development portfolio.
• Manage regulatory preclinical and early clinical development of company’s lead products.
• Manage internal scientific team and external collaboration to achieve A-Mansia’s strategic results.
• Participate in the crafting of business development messages and packaging of the scientific data in view of potential Pharma partnerships.
• Promote innovation and interact with research teams (internal and external)
• Be part of the COMEX, which requires offering help and advice on all of the company’s projects and strategic questions, and report to Board of Directors on the strategic development of operations

Profile:

• You are Ph.D, DVM or MD with at least 10 years of experience in pharma development.
• You have an experience and expertise in protein development as IMPD.
• You have already led ‘translational’ development program(s) from preclinical to early clinical stages.
• You are recognized as a pragmatic and result driven manager and you look for a hands-on position in a cutting-edge scientific field.
• Knowledge of the microbiota field would be a plus.
• Rigorous, detail-oriented, autonomous, committed and flexible.
• Excellent oral and written communication skills in English and French. The command of Dutch is a plus.
• Strong team spirit and excellent interpersonal skills

Offer:

• A strategic and leading position with a high potential innovative and young biotech company
• To work in a human-sized, collaborative and respectful environment
• To take part in a challenging and cutting-edge development program
• An attractive compensation package in line with the position’s responsibilities and your experience.

Nous traitons votre candidature rapidement et de manière strictement confidentielle.

R&D Engineer

Responsibilities:

As a R&D Engineer, you lead and take care of designing, developing and testing the next generation of iStar implants and delivery systems from the concept phase to human use. In collaboration with other team members, you identify innovative and reliable product designs. Reporting to the VP Operations/R&D Director, you play a key role in the R&D/innovation activities.

Your main responsibilities are:

• You conceptualize, design and develop the delivery systems, including design requirements, prototype developments, feasibility evaluations, pre-clinical and clinical assessments.
• You perform and document literature reviews to support customer requirements/design inputs identification, protocol design, pre-clinical studies.
• You support the development of new test methods, tooling and equipment procurement, and executing long term testing for the delivery tool.
• You manage suppliers to develop new products.
• You collaborate with colleagues and physicians in clinical developments in order to evaluate technology and to have a better understanding of ocular anatomy.
• You work with team members and external partners to deliver project’s technical objectives.
• You report results and work evolution on a regular basis to the top management.

Profile:

• Mechanical or Biomedical Engineering Master’s degree.
• Around 5 year’s experience in design, development and industrialization of medical products.
• Experience in medical device design (implant and/or instruments), usability engineering and manufacturing is an asset.
• Familiar with FDA, GMP, QSR and ISO13485 requirements is a plus.
• Strong innovation and communication skills together with hands-on and pragmatic mind-set.
• Very good organizational, analytical and problem solving skills.
• Highly collaborative, self-motivated and team-oriented individual in a company setting.
• Excellent oral and written communication skills in English. Any other language is a plus.
• You are prone to travel worldwide up to 15% of your work time to support product development and clinical investigation trials.

Offer:

• A full-time permanent position within a high-potential medical device company with direct impact on the lives of patients.
• A professional, dynamic and stimulating work environment.
• A variety of interesting contacts with international exposure.
• An attractive compensation package in line with the position responsibilities and your experience.

Nous traitons votre candidature rapidement et de manière strictement confidentielle.

Nous traitons votre candidature rapidement et de manière strictement confidentielle.

Laboratory Logistics Coordinator

Function :

Reporting to the Associate Director, Operations, the Laboratory Coordinator is responsible for the instrument logistics, biosafety, monitoring of instruments and facilities and overall management of laboratory area.

Tasks include :

• Scheduling and overseeing external maintenance and calibration of all instruments and equipments;
• Performing internal qualification of basic equipments (i.e. pipette calibration, balance calibration, thermal mapping of storage equipments);
• Ensuring that equipments are used, maintained and calibrated as per SOP;
• Ensuring that equipment log books are complete and properly maintained; ensuring that calibration reports are completed in a timely manner;
• Managing all instruments and equipment malfunctions and associated documentation as per SOP;
• Purchasing of new equipments (obtaining quotes, ensuring that IQ/OQ/PQ is performed and documented as per SOP);
• Management of the monitoring system for facilities and instruments;
• Ensuring laboratory areas are adequately maintained (planning of maintenance, repair, decontamination and cleaning of laboratory space);
• Managing Health and Biosafety for the site;
• Training laboratory personel on laboratory biosafety rules and equipment operations;
• Participating to the writing and review of laboratory equipment SOP;
• Ensuring that all above laboratory management activities are documented according to GDP procedures;
• Participating in client and/or regulatory agencies audits.

Profile of the applicant :

The applicant must hold a bachelor degree (or the equivalent) in a life science discipline such as biology, medical biology or biochemistry/biotechnology.  The applicant must have a minimum of 5 years in a similar position. Experience in working in a Quality environment is an asset.

The applicant must :

• Be meticulous, thorough and proactive;
• Demonstrate excellent organizational skills;
• Demonstrate schedule adaptability and flexibility.
• Be willing to actively participate to the generation, the implementation and the continuous improvement of laboratory processes.
• Be willing to work in a Quality environment (ISO15189, GCLP, GMP) and apply good documentation procedures (GDP).
• Be functional in French and English (spoken and written).

Offer :

• Full time permanent contract, with possibility of rapid start.
• A professional, dynamic and stimulating work environment.
• A competitive salary package including benefits, adapted to your experience and the context.

Nous traitons votre candidature rapidement et de manière strictement confidentielle.

Research Assistant – Flow Cytometry and Serology – Evenings and weekends

Function :

Reporting to the Associate Director, Operations and working closely with Principal Scientists, the Research Assistant will work within a team focusing on the characterization of the cellular (ELISPOT and various flow cytometry assays such as phenotyping of PBMC, detection of intra-cellular cytokines, etc) and of the humoral (ELISA, Luminex, viral neutralization tests, etc) immune response. You will receive a strong training to further develop your skills in cellular and humoral immunology.

Tasks include :

• Perform immunoassays according to current standard operating procedures;
• Participate to the writing and/or to the review of method SOP and worksheets;
• Manage reagents inventories and orders;
• Participate to the technical management of the laboratory;
• Perform work according to internal quality standards, apply relevant Quality System procedures and participate to the continuous improvement of Quality documents;
• Attend relevant internal training activities;

Profile of the applicant :

The applicant must hold a bachelor degree or a master’s degree (or the equivalent) in a life science discipline such as biology, medical biology or biochemistry/biotechnology.  Practical knowledge of techniques related to cellular and humoral immunology is required.  Experience in cell culture and handling infectious materials in BL2+ environment is an asset.

The applicant must :

• Demonstrate excellent organisational skills.
• Demonstrate schedule adaptability and flexibility.
• Must be able to work evenings and weekend hours.
• Be willing to actively participate to the generation, the implementation and the continuous improvement of laboratory processes.
• Be willing to work in a Quality environment (ISO17025, GCLP, GMP) and apply good documentation procedures (GDP).
• Be functional in French (spoken and written) and have a functional knowledge of written English. Knowledge of spoken English is an asset.

Offer :

• Full time permanent contract, with possibility of rapid start.
• Diversified tasks and responsibilities and interesting projects.
• A professional, dynamic and stimulating work environment.
• Strong training and development opportunities.
• A competitive salary package including benefits (and premium for evenings and weekend hours), adapted to your experience and the context.

Nous traitons votre candidature rapidement et de manière strictement confidentielle.

Nous traitons votre candidature rapidement et de manière strictement confidentielle.

Clinical Trial Manager

Responsibilities:

Reporting directly to the Director of Clinical Operations and working closely with the team in Spain, you are responsible for the operational management and the oversight of clinical trials according to the clinical strategy.

Your main responsibilities are:

• Coordinate clinical trial in collaboration with selected CRO.
• Visit clinical study sites regularly and interact with study members.
• Ensure successful execution of the clinical trials on time and on budget.
• Review study related documentation and materials.
• Co-monitor clinical study for protocol adherence and safety with selected CRO.
• Ensure that clinical trial activities are documented in accordance with regulatory requirement.
• Create and maintain effective relationships with KOL.
• Report results and work evolution on a regular basis to the Director of Clinical Operations.

Profile:

• Master’s or bachelor’s degree in Life Science or equivalent through experience.
• At least 5 years of relevant experience in clinical trials.
• Extensive knowledge of all aspects of GCP and regulations.
• Track record on managing clinical studies on time & on budget.
• Good collaboration, documentation and presentation skills.
• Flexibility, good time management, team-working skills, stress resistant, ability to work proactively and independently.
• Well-developed communication skills, problem solving skills, creative and critical thinking.
• Excellent command of Microsoft Office Tools (Excel, Word, PowerPoint).
• Fluent in English. A good command of French or Catalan is an asset.
• Prepared to travel to Spanish site regularly, clinical investigational sites, conferences and meeting with regulators.

Offer:

• An interesting position within a high-potential clinical stage biotech company.
• The opportunity to work in a human-sized and multicultural team environment.
• A variety of interesting contacts with international exposure.
• An attractive salary package in line with the position responsibilities and your experience.

Interested ?

Nous traitons votre candidature rapidement et de manière strictement confidentielle.

Principal Scientist

Responsibilities :

Reporting to the Director of Scientific Operations and working closely with the laboratory personnel, the Principal Scientist will work within a team focusing on the characterization of the cellular and humoral immune response, using various types of assays such as flow cytometry (phenotypic, ICS, etc) ELISPOT, ELISA, Luminex and viral neutralization tests.

Responsibilities include:

• Overseeing experimental design of flow cytometry, ELISPOT and antibody-based assays through generation of study-specific workplans and supporting documentation
• Acting as a key resource to provide guidance and support in root cause analysis and impact assessment
• Overall conduct of studies in different immune-therapeutic areas, acting as primary contact to the client for communication of study progress
• Data interpretation, report generation and presentation of results to clients

Profile :

The applicant must hold a doctorate degree in life science, with strong knowledge of immunology, with post-doctoral experience (or equivalent) and have a deep expertise of flow cytometry analysis. The applicant must also have a minimum of two years of experience in the industry.

The applicant must :

• Be proficient with analysis software such as FlowJo, Pestle, Spice, Prism and Excel and be able to perform complex analysis of flow cytometry data such as Boolean analysis.
• Demonstrate excellent communication and organisational skills.
• Be abreast of latest immune monitoring methodologies
• Have an excellent knowledge and understanding of GCLP regulations and other regulatory guidelines sufficient to carry out GCLP studies.
• Be willing to work in a Quality environment (ISO17025, GCLP, GMP) and apply good documentation practices (GDP).
• Be fluent in English (written & spoken) and able to functionally communicate in French.

Offer :

• Full time permanent contract.
• Diversified tasks and responsibilities and interesting projects.
• A professional, dynamic and stimulating work environment.
• Development opportunities.
• A competitive salary package including benefits, adapted to your experience and the context.

Nous traitons votre candidature rapidement et de manière strictement confidentielle.

Research Assistant – Flow Cytometry and Serology

Responsibilities :

Reporting to the Laboratory Manager and working closely with Principal Scientists, the Research Assistant will work within a team focusing on the characterization of the cellular (ELISPOT and various flow cytometry assays such as phenotyping of PBMC, detection of intra-cellular cytokines, etc) and of the humoral (ELISA, Luminex, viral neutralization tests, etc) immune response.

Tasks include :

• Perform immunoassays according to current standard operating procedures;
• Participate to the writing and/or to the review of method SOP and worksheets;
• Manage reagents inventories and orders;
• Participate to the technical management of the laboratory;
• Perform work according to internal quality standards, apply relevant Quality System procedures and participate to the continuous improvement of Quality documents;
• Attend relevant internal training activities;
• Depending on the experience level of the candidate, additional tasks may include:
  • Act as a leader in the laboratory for specific studies;
  • Work with the Principal Scientist to prepare experimental plans needed for the conduct of immune monitoring assays;
  • Participate in the development and qualification/validation of complex methods;
  • Participate in experiment planning and problem solving.

Profile :

The applicant must hold a bachelor degree or a master’s degree (or the equivalent) in a life science discipline such as biology, medical biology or biochemistry/biotechnology and demonstrate a relevant laboratory experience. Theoretical and practical knowledge of techniques related to cellular and humoral immunology is required. Experience in cell culture and handling infectious materials in BL2+ environment is an asset.

The applicant must :

• Demonstrate excellent organisational skills.
• Demonstrate schedule adaptability and flexibility.
• Be willing to actively participate to the generation, the implementation and the continuous improvement of laboratory processes.
• Be willing to work in a Quality environment (ISO17025, GCLP, GMP) and apply good documentation procedures (GDP).
• Be functional in French (spoken and written) and have a functional knowledge of written English. Knowledge spoken English is an asset.

Offer :

• Full time permanent contract, with possibility of rapid start.
• Diversified tasks and responsibilities and interesting projects.
• A professional, dynamic and stimulating work environment.
• Training and development opportunities.
• A competitive salary package including benefits, adapted to your experience and the context.

Nous traitons votre candidature rapidement et de manière strictement confidentielle.